López-Otín, Carlos PhD
Visiting Scientist at
Universidad de Oviedo (UNIOVI)
Leading researcher
with 618 publications
ORCID:
0000-0001-6964-1904
Carlos López-Otín is a Professor of Biochemistry and Molecular Biology at the University of Oviedo (Spain). His academic training took place at the Universities of Zaragoza and Complutense of Madrid, where he was awarded his PhD in 1984. His scientific work has been developed at the Centro Ramón y Cajal in Madrid, the Severo Ochoa Molecular Biology Center in Madrid, and the Universities of Lund-Sweden, New York and Harvard-USA. Currently, Carlos López-Otín combines his teaching responsibilities at the University of Oviedo, with his research lines on Cancer and Aging Biology as well as on the Functional Analysis of Genomes. Shortly after his arrival at the University of Oviedo more than 25 years ago, Carlos Lopez-Otin focused on the study of the involvement of proteolytic systems in pathological processes, especially in cancer. The work of Lopez-Otin’s laboratory in this field has yielded the identification of more than 60 novel human proteases dysregulated in different malignant tumors. They have also delineated essential biological information in regards to the functional role of many of these genes in cancer and in other pathological processes, including the devastating syndromes of accelerated aging. They have also proposed a global approach for the study of proteases in health and disease through novel concepts such as Degradomics and Degradome, together with the development (in collaboration with Chris Overall) of high-throughput methods that tackle these concepts. In parallel studies, the Lopez-Otin group has been involved in the functional annotation of the human genome and other genomes and degradomes of biomedical and evolutionary relevance, from chimpanzees and other primates to mice and whales. Since 2009, Carlos Lopez-Otin co-directs the Spanish contribution to the International Cancer Genome Consortium (ICGC-CLL). This scientific work has led to the unveiling of the complete tumor genome sequence of hundreds of patients with chronic lymphocytic leukemia and to the identification of recurrent mutations in several genes, which have become preferential targets for therapeutic intervention in this frequent neoplasia. The work of Lopez-Otin’s laboratory in molecular oncology has also led to the discovery of several proteases with paradoxical anti-tumor and anti-metastatic-properties, as well as two new genes implicated in the progression of head and neck carcinomas. Closely related to the Cancer Genome projects, Lopez-Otin’s group has identified the genetic determinants of several hereditary diseases. Foremost amongst these studies is the discovery of two novel premature aging syndromes, the Nestor-Guillermo Progeria Syndrome (NGPS) and the Atypical Neonatal Progeria Syndrome (ANPS). Their work has also led to the finding of genes causing hereditary sudden death, microcytic anemia, bone abnormalities and familial melanoma. These genomic studies have represented the basis of the creation by Carlos Lopez-Otin of a program called Social Genomics, which has made it possible to study and in some cases to unveil the genomic basis of inherited diseases from families coming to his laboratory in search for help, health and knowledge. The work of Lopez-Otin’s group at the University of Oviedo has also contributed to clarify the molecular mechanisms associated with physiological aging and their links with cancer. They have also reported the first integrative analysis of the molecular and cellular hallmarks of aging and proposed different strategies for the metabolic control of longevity. Moreover, they have recently developed a method to facilitate the cell reprogramming of aged human cells to pluripotent cells with embryonic properties. Finally, the Lopez-Otin’s group has identified a new loss-of-proteostasis mechanism of myeloid transformation, connecting age-associated alterations in hematopoietic stem cells with the pathogenesis of hematological malignancies.These works have been collected in roughly 400 articles in
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Evolution over the last 10 years of activity
Aggregated career metrics
618
Total documents
7.63
Normalized Impact
267
Highly Cited Papers (10%)
44.98
International Collab. (%)
Most cited publications
Main coauthors
Following you can review Carlos's accomplishments in each of the dimensions.
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Dimensions One by One
Spanning 73 diverse indicators, the dimensions considered capture a comprehensive spectrum of academic
attributes.
Each dimension includes a set of indicators and has a especific weight on the One Index.
More information here...
Activity
991
/1000
Reflects an author's research output.
Impact
974
/1000
Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.
Excellence
973
/1000
Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.
Leadership
814
/1000
Reflects an author's efforts and commitment in leading research initiatives.
Cooperation
942
/1000
Reflects a researcher's ability to navigate and thrive in varied academic and research environments, highlighting adaptability, resourcefulness, and the capacity to build and maintain collaborative relationships across the spectrum of their career.
Openness
956
/1000
Reflects an author's commitment to making their research freely accessible and open to the public.
Community Support
0
/1000
Reflects an author's contributions to the academic community beyond their own research.
Community Recognition
0
/1000
Reflects the academic community's acknowledgment and appreciation of an author's contributions.
Transference
554
/1000
Reflects an author's commitment to making their research a practical application and real-world impact of an author's research.
Fundraising
0
/1000
Reflects an author's ability in securing project funding from major global entities, showcasing your ability to drive research initiatives forward.
All indicators
Performance
Activity
Reflects an author's research output.
| Documents | 618 | Count of all document types. |
|---|---|---|
| Docs/Year | 14.37 | Average of documents published by author per year. |
| Citable docs | 569 | Count of journal articles, proceeding papers and reviews. |
| Journal Articles | 497 | Documents published as articles in scientific journals usually peer-reviewed. |
| Conferences | 6 | Original article reporting data presented at a conference or symposium. |
| Reviews | 66 | Review papers authored by the researcher. |
| Patents | 0 | Intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an enabling disclosure of the invention. |
| Theses | 0 | Document submitted in support of candidature for an academic degree or professional qualification presenting the author's research and findings |
| Books | 0 | A whole monograph or the entire book. |
| Book Chapters | 0 | Complete chapter in a book or book series volume where the item is identified as a chapter by a heading or section indicator. |
| Datasets | 9 | Number of dataset where the author have contributed to the creation. |
| Editorials | 2 | Papers where the author contributed editorial content. |
| Reports | 2 | Research reports or white papers authored. |
| Grants | 0 | Research projects funded through external grants awarded to the author. |
| Pre-Prints | 11 | Number of publications freely available in pre-print format. |
| Clinical Trials | N/A | Number of clinical trials where the author has participated. |
| Other types | 0 | Other type of documents. |
Impact
Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.
| Citations | 119295 | Total number of citations to all the publications attributed to the author (all types). |
|---|---|---|
| Self Citations | 2586 | Citations where the author references their own previous work. |
| Self Citation Rate | 2.168 | Percentage of self-citations in the author's total citation count. |
| Non Self Citation Rate | 97.832 | Percentage of citations received from sources that are not self-citations. |
| Hot Citations | 4729 | Total number of citations recieved in the last 6 months. |
| Citations/Document | 193.03 | Average of citations recieved per document. |
| % Not Cited | 0.0 | Percentage of documents with no citations recieved. |
| Relative Citation Index | 7.629 | Item oriented indicator consisting of the quotient between the number of citations to a given work and the average number of citations to works of the same type, year and discipline. An author's RCI corresponds to the average of the values of his/her publications. |
| Journal Relative Citation Index | 2.678 | Item oriented indicator consisting of the quotient between the number of citations to a given work and the average number of citations to works of the same type, year and journal. An author's RCI corresponds to the average of the values of his/her publications. |
| H Index | 143 | Maximum value of h such that the given author has published at least h papers that have each been cited at least h times. |
| G Index | 338 | Maximum value of g such that the given author has published at least g papers that have each been cited at least g^2 times. |
| i10 Index | 469 | Number of documents with at least 10 citations recieved. |
Excellence
Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.
| Citation Score | 0.749 | Ratio between 0 and 1 being 0 corresponding to the citation percentile being 0 the 0th and 1 the 100th. |
|---|---|---|
| Citation Normalized Percentile | 0.757 | Citation percentile normalized to 1 (0 worst, 1 best) of the position in citations rankin within the field. Provided by OpenAlex. |
| Higly Cited Papers (top 10%) | 267 | Count of publications falling on or above the 90th citation percentile in the cohort of publications of the same type, year and discipline. |
| Relative Higly Cited Papers | 4.32 | Quotient between the real number of Highly Cited Papers (HCP) and expected number of HCP's that is the 10% of total documents. |
| Outstanding Papers (top 1%) | 73 | Count of publications falling on or above the 99th citation percentile in the cohort of publications of the same type, year and discipline. |
| Relative Outstanding Papers | 11.812 | Quotient between the real number of Outstanding Papers (OP) and expected number of OP's that is the 1% of total documents. |
| Outstanding Papers (top 0.1%) | 23 | Count of publications falling on or above the 99.9th citation percentile in the cohort of publications of the same type, year and discipline. |
| Hot Papers | 64 | Using only the citations recieved in the last 6 months: documents falling on or above the 99th citation percentile in the cohort of publications of the same type, year and discipline. |
Interaction within community
Leadership
Reflects an author's efforts and commitment in leading research initiatives.
| Docs Leadership | 264 | Number of documents lead by the author. |
|---|---|---|
| % Leadership | 42.72 | Percentage of documents lead by the author. |
| Docs International Leadership | 82 | Number of documents in international collaboration lead by the author. |
| % International Leadership | 13.27 | Percentage of documents in international collaboration lead by the author. |
| Principal Investigator | 0 | Number of times where the author served as the lead researcher in a project. |
| Associations Founded | 0 | Number of associations founded by the author. |
| Societies Founded | 0 | Number of scientific or professional societies established by the author. |
| Foundations Founded | 0 | Number of research-related foundations established by the author. |
| Councils | 0 | Number of councils founded by author. |
Cooperation
Reflects a researcher's ability to navigate and thrive in varied academic and research environments, highlighting adaptability, resourcefulness, and the capacity to build and maintain collaborative relationships across the spectrum of their career.
| Authors/Paper | 88.06 | Average number of authors per document. |
|---|---|---|
| % Highly Authored Papers | 15.7 | Percentage of documents with 25 or more authors. |
| Countries/Paper | 3.06 | Average number of different countries in the author's affiliation line per document. |
| Docs International Collaboration | 278 | Number of documents reporting two or more different countries in the author's affiliation line. |
| % International Collaboration | 44.98 | Percentage of documents reporting two or more diffetent countries in the author's affiliation line. |
Community Support
Reflects an author's contributions to the academic community beyond their own research.
| Peer Review Counts | 0 | Number of times the author peer-reviewed publications. |
|---|---|---|
| Society Membership | 0 | Number of societies of wich the author is a member. |
| Society Memberships | 0 | Memberships held by the author in scientific or professional societies. |
| Editorial Board Memberships | 0 | Number of journals where the author has been member of editorial board. |
| Panelists | 0 | Number of times the author have been a panelist in the European Research Council (ERC) calls. |
Community Recognition
Reflects the academic community's acknowledgment and appreciation of an author's contributions.
| Distinctions | 0 | Number of times the author have recieved a distinction for its career. |
|---|---|---|
| Invitations | 0 | Number of times the author has been invited to talks, professorships, expositions or demonstrations. |
| Talks | 0 | Number of times the author has been invited to talks. |
| Professorships | 0 | Number of times the author has been invited to professorhips. |
| Commissioned Reports | 0 | Commissioned reports done by the author. |
Interaction with society
Openness
Reflects an author's commitment to making their research freely accessible and open to the public.
| Open Access Documents | 401 | Number of documents in Open Access mode. |
|---|---|---|
| % Open Access Documents | 64.89 | Percentage of documents in Open Access mode. |
| Open Access Gold | 79 | Number of documents published in an OA journal that is indexed by the DOAJ. |
| Open Access Green | 78 | Toll-access on the publisher landing page, but there is a free copy in an OA repository. |
| Open Access Hybrid | 97 | Free under an open license in a toll-access journal. |
| Open Access Bronze | 144 | Free to read on the publisher landing page, but without any identifiable license. |
| Open Access Closed | 217 | Non Open Access documents. |
Transference
Reflects an author's commitment to making their research a practical application and real-world impact of an author's research.
| Patents | 0 | Intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an enabling disclosure of the invention. |
|---|---|---|
| Advisory Boards | 0 | Number of advisory boards of which the author is member. |
| Companies | 0 | Number of companies created or founded by the author. |
Fundraising
Reflects an author's ability in securing project funding from major global entities, showcasing your ability to drive research initiatives forward.
| Funding Counts | 0 | Number of activities reported as funding recieved. |
|---|---|---|
| ERC Grantees | 0 | Researchers awarded grants from the European Research Council. |