Parkes, Miles PhD
Professor at
Addenbrooke's Hospital, Cambridge
Leading researcher
with 325 publications
ORCID:
0000-0002-6467-0631
I have been an NHS consultant gastroenterologist at Cambridge University Hospital since 2001. I was appointed as director of the Cambridge Biomedical Research Centre and awarded an honorary chair by the University of Cambridge in 2020. My clinical and research interests are in Crohn’s disease and ulcerative colitis (collectively inflammatory bowel disease or IBD). I am recognised as one of the leading global investigators in IBD pathogenesis and particularly IBD genetics. According to Google Scholar my H index is 76 with >27,000 citations from 34 publications in the last 5 years (7 in Nature Genetics, 2 in Cell, 1 in each of Nature and the Lancet). Ten of the papers on which I have played a key role have over 1000 citations, including one on which I was first author (1395 citations) and another the senior author (2830 citations). IBD exacts a huge toll on patients’ lives and NHS budgets. Improved treatment outcomes require better understanding of IBD pathogenic pathways and determinants of severity. My research aims to identify these; and target them for clinical benefit. My basic training in IBD genetics occurred in Oxford at the Wellcome Trust Centre for Human Genetics where I undertook a 3.5 year MRC research training fellowship supervised by John Bell and Derek Jewell. I moved to Cambridge in 2001 and established the East of England IBD genetics research programme. I founded and have led the UK IBD genetics consortium for 15 years, and was co-PI and management committee member for the Wellcome Trust Case Control Consortium. These collaborations led to seminal early GWAS studies in Crohn's disease (WTCCC, Nature 2007; Parkes et al, Nature Genetics 2007). With regard to ulcerative colitis we provided the first detailed insights into the molecular genetic overlap between ulcerative colitis and Crohn's disease (Fisher et al, Nature Genetics 2008). With WTCCC we subsequently undertook a full GWAS in UC (Barrett et al, Nature Genetics 2009). GWAS remains a key technology by which we identify new IBD pathogenic pathways (de Lange et al Nature Genetics 2017) although increasingly we are using whole genome or whole exome sequencing in our studies (Luo et al Nature Genetics 2017). In 2007, with other group leaders from the UK, North America and Europe, I founded the international IBD genetics consortium and chaired this group for its first 3 years. During this period we published 3 reports in Nature Genetics (Barrett et al, 2008; Franke et al, 2010 and Anderson et al, 2011) and laid the groundwork for the Immunochip study in which we genotyped >40,000 patients with IBD and identified 163 independent genome-wide significant loci (Jostins et al, Nature 2012). Additional publications have followed in Nature, Nature Genetics and the Lancet. Collaborating with Ken Smith I helped in the development of an accurate biomarker of IBD prognosis based on gene expression profiling in CD8+ T cells (Lee et al, JCI 2011). The genetic variants underlying the signature have been functionally interrogated (Lee et al, Cell 2015). This has been developed for a biomarker-stratified trial in early Crohn's disease - the first stratified medicine trial in inflammatory disease - funded by the Wellcome Trust. I am national Chief Investigator for this study. Also playing to the theme of stratified medicine in Crohn’s disease, we have recently identified a number of loci associated with disease course / prognosis as opposed to disease susceptibility (Lee et al, Nature Genetics 2017). I have collaborated on a number of studies investigating the role of the microbiota in IBD, with investigators in the US and UK – published in Cell (2015) and recently in Immunity (2019) and Gut Microbes (2019). We have recently been awarded a $1.4 million NIH grant to continue work on the virome in IBD. I am Chief Investigator for the national IBD BioResource, funded by the MRC and NIHR. Since 2016 we have recruited >34,000 patients with IBD who can be recalled by phenot
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Evolution over the last 10 years of activity
Aggregated career metrics
325
Total documents
6.71
Normalized Impact
99
Highly Cited Papers (10%)
32.31
International Collab. (%)
Most cited publications
Main coauthors
Following you can review Miles's accomplishments in each of the dimensions.
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Dimensions One by One
Spanning 73 diverse indicators, the dimensions considered capture a comprehensive spectrum of academic
attributes.
Each dimension includes a set of indicators and has a especific weight on the One Index.
More information here...
Activity
802
/1000
Reflects an author's research output.
Impact
964
/1000
Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.
Excellence
970
/1000
Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.
Leadership
516
/1000
Reflects an author's efforts and commitment in leading research initiatives.
Cooperation
950
/1000
Reflects a researcher's ability to navigate and thrive in varied academic and research environments, highlighting adaptability, resourcefulness, and the capacity to build and maintain collaborative relationships across the spectrum of their career.
Openness
971
/1000
Reflects an author's commitment to making their research freely accessible and open to the public.
Community Support
153
/1000
Reflects an author's contributions to the academic community beyond their own research.
Community Recognition
979
/1000
Reflects the academic community's acknowledgment and appreciation of an author's contributions.
Transference
0
/1000
Reflects an author's commitment to making their research a practical application and real-world impact of an author's research.
Fundraising
0
/1000
Reflects an author's ability in securing project funding from major global entities, showcasing your ability to drive research initiatives forward.
All indicators
Performance
Activity
Reflects an author's research output.
| Documents | 325 | Count of all document types. |
|---|---|---|
| Docs/Year | 4.28 | Average of documents published by author per year. |
| Citable docs | 289 | Count of journal articles, proceeding papers and reviews. |
| Journal Articles | 237 | Documents published as articles in scientific journals usually peer-reviewed. |
| Conferences | 20 | Original article reporting data presented at a conference or symposium. |
| Reviews | 32 | Review papers authored by the researcher. |
| Patents | 0 | Intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an enabling disclosure of the invention. |
| Theses | 0 | Document submitted in support of candidature for an academic degree or professional qualification presenting the author's research and findings |
| Books | 0 | A whole monograph or the entire book. |
| Book Chapters | 0 | Complete chapter in a book or book series volume where the item is identified as a chapter by a heading or section indicator. |
| Datasets | 0 | Number of dataset where the author have contributed to the creation. |
| Editorials | 0 | Papers where the author contributed editorial content. |
| Reports | 0 | Research reports or white papers authored. |
| Grants | 0 | Research projects funded through external grants awarded to the author. |
| Pre-Prints | 14 | Number of publications freely available in pre-print format. |
| Clinical Trials | N/A | Number of clinical trials where the author has participated. |
| Other types | 0 | Other type of documents. |
Impact
Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.
| Citations | 46236 | Total number of citations to all the publications attributed to the author (all types). |
|---|---|---|
| Self Citations | 546 | Citations where the author references their own previous work. |
| Self Citation Rate | 1.181 | Percentage of self-citations in the author's total citation count. |
| Non Self Citation Rate | 98.819 | Percentage of citations received from sources that are not self-citations. |
| Hot Citations | 1665 | Total number of citations recieved in the last 6 months. |
| Citations/Document | 142.26 | Average of citations recieved per document. |
| % Not Cited | 0.0 | Percentage of documents with no citations recieved. |
| Relative Citation Index | 6.711 | Item oriented indicator consisting of the quotient between the number of citations to a given work and the average number of citations to works of the same type, year and discipline. An author's RCI corresponds to the average of the values of his/her publications. |
| Journal Relative Citation Index | 2.906 | Item oriented indicator consisting of the quotient between the number of citations to a given work and the average number of citations to works of the same type, year and journal. An author's RCI corresponds to the average of the values of his/her publications. |
| H Index | 68 | Maximum value of h such that the given author has published at least h papers that have each been cited at least h times. |
| G Index | 193 | Maximum value of g such that the given author has published at least g papers that have each been cited at least g^2 times. |
| i10 Index | 136 | Number of documents with at least 10 citations recieved. |
Excellence
Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.
| Citation Score | 0.57 | Ratio between 0 and 1 being 0 corresponding to the citation percentile being 0 the 0th and 1 the 100th. |
|---|---|---|
| Citation Normalized Percentile | 0.563 | Citation percentile normalized to 1 (0 worst, 1 best) of the position in citations rankin within the field. Provided by OpenAlex. |
| Higly Cited Papers (top 10%) | 99 | Count of publications falling on or above the 90th citation percentile in the cohort of publications of the same type, year and discipline. |
| Relative Higly Cited Papers | 3.046 | Quotient between the real number of Highly Cited Papers (HCP) and expected number of HCP's that is the 10% of total documents. |
| Outstanding Papers (top 1%) | 45 | Count of publications falling on or above the 99th citation percentile in the cohort of publications of the same type, year and discipline. |
| Relative Outstanding Papers | 13.846 | Quotient between the real number of Outstanding Papers (OP) and expected number of OP's that is the 1% of total documents. |
| Outstanding Papers (top 0.1%) | 13 | Count of publications falling on or above the 99.9th citation percentile in the cohort of publications of the same type, year and discipline. |
| Hot Papers | 36 | Using only the citations recieved in the last 6 months: documents falling on or above the 99th citation percentile in the cohort of publications of the same type, year and discipline. |
Interaction within community
Leadership
Reflects an author's efforts and commitment in leading research initiatives.
| Docs Leadership | 88 | Number of documents lead by the author. |
|---|---|---|
| % Leadership | 27.08 | Percentage of documents lead by the author. |
| Docs International Leadership | 16 | Number of documents in international collaboration lead by the author. |
| % International Leadership | 4.92 | Percentage of documents in international collaboration lead by the author. |
| Principal Investigator | 0 | Number of times where the author served as the lead researcher in a project. |
| Associations Founded | 0 | Number of associations founded by the author. |
| Societies Founded | 0 | Number of scientific or professional societies established by the author. |
| Foundations Founded | 0 | Number of research-related foundations established by the author. |
| Councils | 0 | Number of councils founded by author. |
Cooperation
Reflects a researcher's ability to navigate and thrive in varied academic and research environments, highlighting adaptability, resourcefulness, and the capacity to build and maintain collaborative relationships across the spectrum of their career.
| Authors/Paper | 70.88 | Average number of authors per document. |
|---|---|---|
| % Highly Authored Papers | 32.62 | Percentage of documents with 25 or more authors. |
| Countries/Paper | 2.04 | Average number of different countries in the author's affiliation line per document. |
| Docs International Collaboration | 105 | Number of documents reporting two or more different countries in the author's affiliation line. |
| % International Collaboration | 32.31 | Percentage of documents reporting two or more diffetent countries in the author's affiliation line. |
Community Support
Reflects an author's contributions to the academic community beyond their own research.
| Peer Review Counts | 0 | Number of times the author peer-reviewed publications. |
|---|---|---|
| Society Membership | 2 | Number of societies of wich the author is a member. |
| Society Memberships | 0 | Memberships held by the author in scientific or professional societies. |
| Editorial Board Memberships | 0 | Number of journals where the author has been member of editorial board. |
| Panelists | 0 | Number of times the author have been a panelist in the European Research Council (ERC) calls. |
Community Recognition
Reflects the academic community's acknowledgment and appreciation of an author's contributions.
| Distinctions | 2 | Number of times the author have recieved a distinction for its career. |
|---|---|---|
| Invitations | 1 | Number of times the author has been invited to talks, professorships, expositions or demonstrations. |
| Talks | 0 | Number of times the author has been invited to talks. |
| Professorships | 0 | Number of times the author has been invited to professorhips. |
| Commissioned Reports | 0 | Commissioned reports done by the author. |
Interaction with society
Openness
Reflects an author's commitment to making their research freely accessible and open to the public.
| Open Access Documents | 233 | Number of documents in Open Access mode. |
|---|---|---|
| % Open Access Documents | 71.69 | Percentage of documents in Open Access mode. |
| Open Access Gold | 26 | Number of documents published in an OA journal that is indexed by the DOAJ. |
| Open Access Green | 56 | Toll-access on the publisher landing page, but there is a free copy in an OA repository. |
| Open Access Hybrid | 49 | Free under an open license in a toll-access journal. |
| Open Access Bronze | 100 | Free to read on the publisher landing page, but without any identifiable license. |
| Open Access Closed | 92 | Non Open Access documents. |
Transference
Reflects an author's commitment to making their research a practical application and real-world impact of an author's research.
| Patents | 0 | Intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an enabling disclosure of the invention. |
|---|---|---|
| Advisory Boards | 0 | Number of advisory boards of which the author is member. |
| Companies | 0 | Number of companies created or founded by the author. |
Fundraising
Reflects an author's ability in securing project funding from major global entities, showcasing your ability to drive research initiatives forward.
| Funding Counts | 14 | Number of activities reported as funding recieved. |
|---|---|---|
| ERC Grantees | 0 | Researchers awarded grants from the European Research Council. |