Author avatar

Roder, Heinrich  PhD

Researcher with 293 publications
Throughout my scientific career I have been fascinated by basic problems in protein science, including the mechanism of protein folding, protein structure-function relationships, and the impact of protein dynamics and intrinsic disorder on protein function. My group approaches these fundamental questions using various biophysical tools, including NMR, fluorescence and other optical techniques, rapid kinetics and protein engineering. Some of our most notable contributions include the development of NMR-based hydrogen exchange labeling methods and improved rapid mixing techniques, which have led to a better understanding of early stages of protein folding. These innovative methodologies, combined with rigorous kinetic modeling and protein engineering, have enabled us to characterize the folding/unfolding mechanisms of numerous proteins in great detail, both in terms of structural and temporal resolution. Our observation that proteins of various sizes and structural types encounter compact, partially structured states during early stages of folding have had a profound impact on the field. Our current research is mainly directed at understanding mechanisms of coupled folding/binding reactions. In parallel, we have made extensive use of biomolecular NMR and fluorescence techniques for exploring structure-dynamics-function relationships of a variety of proteins, including de novo designed proteins, a blood clotting factor, several signaling proteins and the inhibitory natural killer cell receptor KIR3DL1, often in collaboration with colleagues at Fox Chase, U. Penn. or Temple U. In a recently completed NIH-funded project we explored the structure, dynamics and interactions of NHERF, a signaling scaffold comprising a pair of PDZ domains as well as long intrinsically disordered regions. NHERF functions as an adapter at the membrane-cytoskeleton interface of epithelial cells and regulates the activity of numerous membrane proteins. By combining our biophysical approaches with cellular imaging and flow cytometry, we gained detailed insight into the mechanism by which NHERF regulates the signaling activity and trafficking of the epidermal growth factor receptor (EGFR). Current research is aimed at understanding how interactions between multivalent scaffold proteins, such as NHERF or the SH2-domain containing phosphatase SHP2, with the intrinsically disordered cytosolic regions of membrane receptors, such as EGFR and KIR3DL1, can mediate receptor clustering and phase separation on the plasma membrane. show More

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Evolution over the last 10 years of activity
Aggregated career metrics
293

Total documents

1.82

Normalized Impact

71

Highly Cited Papers (10%)

24.91

International Collab. (%)

Most cited publications


Main coauthors


Following you can review Heinrich's accomplishments in each of the dimensions.

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Dimensions One by One

Spanning 73 diverse indicators, the dimensions considered capture a comprehensive spectrum of academic attributes. Each dimension includes a set of indicators and has a especific weight on the One Index. More information here...

Activity

902
/1000
Reflects an author's research output.

Impact

769
/1000
Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.

Excellence

858
/1000
Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.

Leadership

780
/1000
Reflects an author's efforts and commitment in leading research initiatives.

Cooperation

749
/1000
Reflects a researcher's ability to navigate and thrive in varied academic and research environments, highlighting adaptability, resourcefulness, and the capacity to build and maintain collaborative relationships across the spectrum of their career.

Openness

920
/1000
Reflects an author's commitment to making their research freely accessible and open to the public.

Community Support

149
/1000
Reflects an author's contributions to the academic community beyond their own research.

Community Recognition

0
/1000
Reflects the academic community's acknowledgment and appreciation of an author's contributions.

Transference

387
/1000
Reflects an author's commitment to making their research a practical application and real-world impact of an author's research.

Fundraising

0
/1000
Reflects an author's ability in securing project funding from major global entities, showcasing your ability to drive research initiatives forward.

All indicators

Performance

Activity

Reflects an author's research output.

Documents 293 Count of all document types.
Docs/Year 5.63 Average of documents published by author per year.
Citable docs 274 Count of journal articles, proceeding papers and reviews.
Journal Articles 264 Documents published as articles in scientific journals usually peer-reviewed.
Conferences 2 Original article reporting data presented at a conference or symposium.
Reviews 8 Review papers authored by the researcher.
Patents 0 Intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an enabling disclosure of the invention.
Theses 0 Document submitted in support of candidature for an academic degree or professional qualification presenting the author's research and findings
Books 0 A whole monograph or the entire book.
Book Chapters 0 Complete chapter in a book or book series volume where the item is identified as a chapter by a heading or section indicator.
Datasets 9 Number of dataset where the author have contributed to the creation.
Editorials 0 Papers where the author contributed editorial content.
Reports 1 Research reports or white papers authored.
Grants 0 Research projects funded through external grants awarded to the author.
Pre-Prints 6 Number of publications freely available in pre-print format.
Clinical Trials N/A Number of clinical trials where the author has participated.
Other types 0 Other type of documents.

Impact

Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.

Citations 15320 Total number of citations to all the publications attributed to the author (all types).
Self Citations 814 Citations where the author references their own previous work.
Self Citation Rate 5.313 Percentage of self-citations in the author's total citation count.
Non Self Citation Rate 94.687 Percentage of citations received from sources that are not self-citations.
Hot Citations 97 Total number of citations recieved in the last 6 months.
Citations/Document 52.29 Average of citations recieved per document.
% Not Cited 0.0 Percentage of documents with no citations recieved.
Relative Citation Index 1.819 Item oriented indicator consisting of the quotient between the number of citations to a given work and the average number of citations to works of the same type, year and discipline. An author's RCI corresponds to the average of the values of his/her publications.
Journal Relative Citation Index 1.292 Item oriented indicator consisting of the quotient between the number of citations to a given work and the average number of citations to works of the same type, year and journal. An author's RCI corresponds to the average of the values of his/her publications.
H Index 69 Maximum value of h such that the given author has published at least h papers that have each been cited at least h times.
G Index 116 Maximum value of g such that the given author has published at least g papers that have each been cited at least g^2 times.
i10 Index 165 Number of documents with at least 10 citations recieved.

Excellence

Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.

Citation Score 0.586 Ratio between 0 and 1 being 0 corresponding to the citation percentile being 0 the 0th and 1 the 100th.
Citation Normalized Percentile 0.588 Citation percentile normalized to 1 (0 worst, 1 best) of the position in citations rankin within the field. Provided by OpenAlex.
Higly Cited Papers (top 10%) 71 Count of publications falling on or above the 90th citation percentile in the cohort of publications of the same type, year and discipline.
Relative Higly Cited Papers 2.423 Quotient between the real number of Highly Cited Papers (HCP) and expected number of HCP's that is the 10% of total documents.
Outstanding Papers (top 1%) 4 Count of publications falling on or above the 99th citation percentile in the cohort of publications of the same type, year and discipline.
Relative Outstanding Papers 1.365 Quotient between the real number of Outstanding Papers (OP) and expected number of OP's that is the 1% of total documents.
Outstanding Papers (top 0.1%) 0 Count of publications falling on or above the 99.9th citation percentile in the cohort of publications of the same type, year and discipline.
Hot Papers 5 Using only the citations recieved in the last 6 months: documents falling on or above the 99th citation percentile in the cohort of publications of the same type, year and discipline.

Interaction within community

Leadership

Reflects an author's efforts and commitment in leading research initiatives.

Docs Leadership 137 Number of documents lead by the author.
% Leadership 46.76 Percentage of documents lead by the author.
Docs International Leadership 20 Number of documents in international collaboration lead by the author.
% International Leadership 6.83 Percentage of documents in international collaboration lead by the author.
Principal Investigator 0 Number of times where the author served as the lead researcher in a project.
Associations Founded 0 Number of associations founded by the author.
Societies Founded 0 Number of scientific or professional societies established by the author.
Foundations Founded 0 Number of research-related foundations established by the author.
Councils 0 Number of councils founded by author.

Cooperation

Reflects a researcher's ability to navigate and thrive in varied academic and research environments, highlighting adaptability, resourcefulness, and the capacity to build and maintain collaborative relationships across the spectrum of their career.

Authors/Paper 19.99 Average number of authors per document.
% Highly Authored Papers 1.37 Percentage of documents with 25 or more authors.
Countries/Paper 1.47 Average number of different countries in the author's affiliation line per document.
Docs International Collaboration 73 Number of documents reporting two or more different countries in the author's affiliation line.
% International Collaboration 24.91 Percentage of documents reporting two or more diffetent countries in the author's affiliation line.

Community Support

Reflects an author's contributions to the academic community beyond their own research.

Peer Review Counts 1 Number of times the author peer-reviewed publications.
Society Membership 0 Number of societies of wich the author is a member.
Society Memberships 0 Memberships held by the author in scientific or professional societies.
Editorial Board Memberships 0 Number of journals where the author has been member of editorial board.
Panelists 0 Number of times the author have been a panelist in the European Research Council (ERC) calls.

Community Recognition

Reflects the academic community's acknowledgment and appreciation of an author's contributions.

Distinctions 0 Number of times the author have recieved a distinction for its career.
Invitations 0 Number of times the author has been invited to talks, professorships, expositions or demonstrations.
Talks 0 Number of times the author has been invited to talks.
Professorships 0 Number of times the author has been invited to professorhips.
Commissioned Reports 0 Commissioned reports done by the author.

Interaction with society

Openness

Reflects an author's commitment to making their research freely accessible and open to the public.

Open Access Documents 144 Number of documents in Open Access mode.
% Open Access Documents 49.15 Percentage of documents in Open Access mode.
Open Access Gold 23 Number of documents published in an OA journal that is indexed by the DOAJ.
Open Access Green 61 Toll-access on the publisher landing page, but there is a free copy in an OA repository.
Open Access Hybrid 22 Free under an open license in a toll-access journal.
Open Access Bronze 38 Free to read on the publisher landing page, but without any identifiable license.
Open Access Closed 149 Non Open Access documents.

Transference

Reflects an author's commitment to making their research a practical application and real-world impact of an author's research.

Patents 0 Intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an enabling disclosure of the invention.
Advisory Boards 0 Number of advisory boards of which the author is member.
Companies 0 Number of companies created or founded by the author.

Fundraising

Reflects an author's ability in securing project funding from major global entities, showcasing your ability to drive research initiatives forward.

Funding Counts 10 Number of activities reported as funding recieved.
ERC Grantees 0 Researchers awarded grants from the European Research Council.
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