Boes, Marianne PhD
Associate Professor at
University Medical Center Utrecht
Leading researcher
with 191 publications
in the last 35 years
ORCID:
0000-0003-2590-1692
Marianne Boes heads the pediatric immunology laboratory at the UMC Utrecht, embedded in the Center for Translational Immunology. She focuses all translational research efforts on immune cell communication. The inadequate use of immune pathways can result in disease, such as exemplified in primary immunodeficiency patients, and while immune response modification has already created much positive impact on patient care, there is still much work to be done. First, for chronic inflammatory diseases, treatment in many cases is still based on generalized immune suppression (i.e., DMARDs, disease modifying anti-rheumatic drugs), that may also potentially suppress immune reactivity that ward off infections and malignancy. Second, early experiences of cancer immunotherapy now reveal the occurrence of auto-immunological adverse events, in severe cases leading to diseases including (but not limited to) diabetes and rheumatoid disease. Third, immune response modification holds the promise to prevent the clinical presentation of certain autoimmune and/or immuno-metabolic disorders for which key biomarkers or drivers are already known (i.e., psoriatic arthritis, type I diabetes, early atherosclerosis). This latter research field has been especially under-investigated, and has the focus of her lab. The strength of the immune response and its promise to redirection using immune response modification as preventive medicine is tremendous. Boes works with the premise that its full applicability requires better understanding of immune cell communication, which she pursues by study of well-defined human patient cohorts, for the stratification of patients within such cohorts and to arrive at earlier and more precise disease intervention. Boes trained in the USA in immunology and cell biology research (1996-2008). She performed PhD research at Massachusetts Institute of Technology (MIT), at the Koch Institute for integrative Cancer Research under supervision of prof. Jianzhu Chen. Here she studied immunodeficiency mechanisms using mouse models. Postdoctoral work she performed at Harvard Medical School in the laboratory of prof. Hidde Ploegh, where she discovered the rapid and dynamic endosomal remodeling process in dendritic cells that occurs immediately upon antigen-specific T-cell contact (Boes et al, Nature 2002). In 2004, Dr. Boes started her independent research lab at Brigham and Women’s Hospital/Harvard Medical School, financed in part by an NWO-Veni grant in 2004 and a large NIH-RO1 grant that was awarded to her. In 2008, she moved her lab to the UMC-Utrecht. She published more than 130 articles (H-index 40) in international journals, including Nature, Science, Immunity, J. Exp. Med., Nature Immunology and J. Clin. Invest. She and her group received numerous prestigious national and international grants and awards. Boes serves as senior editor for several peer-reviewed journals and is a regular reviewer for major journals in her field. She is the founding chair of the Young Academy of the UMC Utrecht (chair Sept 2019-Jan 2022) and board member of the Center for Unusual Collaborations (CUCo; working group of the Young Academies of the Strategic Alliance between TU-Eindhoven, Wageningen, Utrecht University and UMC-Utrecht, 2019-2022). Boes serves as coordinator of the course 'Advanced Immunology' for PhD students. She is current member of the I&I graduate school teaching committee. She thoroughly enjoys to meet and learn from researchers, patients and societal partners in different fields. Research in Boes lab is supported financially by grants from NWO, the European Research Council (ERC), the Lymph&co foundation, the strategic alliance TUe, WUR, UU, UMCU (The Power-Of-One project) and several industry partners. Boes collaborates across disciplines with investigators, societal partners and patientgroups at the UMC-Utrecht and beyond. Several collaborative projects exist with labs elsewhere in Europe and in the USA.
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Evolution over the last 10 years of activity
Aggregated career metrics
191
Total documents
4.09
Normalized Impact
47
Highly Cited Papers (10%)
34.03
International Collab. (%)
Most cited publications
Main coauthors
Following you can review Marianne's accomplishments in each of the dimensions.
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Dimensions One by One
Spanning 73 diverse indicators, the dimensions considered capture a comprehensive spectrum of academic
attributes.
Each dimension includes a set of indicators and has a especific weight on the One Index.
More information here...
Activity
878
/1000
Reflects an author's research output.
Impact
842
/1000
Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.
Excellence
771
/1000
Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.
Leadership
826
/1000
Reflects an author's efforts and commitment in leading research initiatives.
Cooperation
785
/1000
Reflects a researcher's ability to navigate and thrive in varied academic and research environments, highlighting adaptability, resourcefulness, and the capacity to build and maintain collaborative relationships across the spectrum of their career.
Openness
951
/1000
Reflects an author's commitment to making their research freely accessible and open to the public.
Community Support
377
/1000
Reflects an author's contributions to the academic community beyond their own research.
Community Recognition
932
/1000
Reflects the academic community's acknowledgment and appreciation of an author's contributions.
Transference
0
/1000
Reflects an author's commitment to making their research a practical application and real-world impact of an author's research.
Fundraising
0
/1000
Reflects an author's ability in securing project funding from major global entities, showcasing your ability to drive research initiatives forward.
All indicators
Performance
Activity
Reflects an author's research output.
| Documents | 191 | Count of all document types. |
|---|---|---|
| Docs/Year | 5.46 | Average of documents published by author per year. |
| Citable docs | 172 | Count of journal articles, proceeding papers and reviews. |
| Journal Articles | 146 | Documents published as articles in scientific journals usually peer-reviewed. |
| Conferences | 3 | Original article reporting data presented at a conference or symposium. |
| Reviews | 23 | Review papers authored by the researcher. |
| Patents | 0 | Intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an enabling disclosure of the invention. |
| Theses | 0 | Document submitted in support of candidature for an academic degree or professional qualification presenting the author's research and findings |
| Books | 0 | A whole monograph or the entire book. |
| Book Chapters | 0 | Complete chapter in a book or book series volume where the item is identified as a chapter by a heading or section indicator. |
| Datasets | 0 | Number of dataset where the author have contributed to the creation. |
| Editorials | 3 | Papers where the author contributed editorial content. |
| Reports | 0 | Research reports or white papers authored. |
| Grants | 0 | Research projects funded through external grants awarded to the author. |
| Pre-Prints | 4 | Number of publications freely available in pre-print format. |
| Clinical Trials | N/A | Number of clinical trials where the author has participated. |
| Other types | 0 | Other type of documents. |
Impact
Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.
| Citations | 16424 | Total number of citations to all the publications attributed to the author (all types). |
|---|---|---|
| Self Citations | 202 | Citations where the author references their own previous work. |
| Self Citation Rate | 1.23 | Percentage of self-citations in the author's total citation count. |
| Non Self Citation Rate | 98.77 | Percentage of citations received from sources that are not self-citations. |
| Hot Citations | 310 | Total number of citations recieved in the last 6 months. |
| Citations/Document | 85.99 | Average of citations recieved per document. |
| % Not Cited | 0.0 | Percentage of documents with no citations recieved. |
| Relative Citation Index | 4.094 | Item oriented indicator consisting of the quotient between the number of citations to a given work and the average number of citations to works of the same type, year and discipline. An author's RCI corresponds to the average of the values of his/her publications. |
| Journal Relative Citation Index | 1.665 | Item oriented indicator consisting of the quotient between the number of citations to a given work and the average number of citations to works of the same type, year and journal. An author's RCI corresponds to the average of the values of his/her publications. |
| H Index | 47 | Maximum value of h such that the given author has published at least h papers that have each been cited at least h times. |
| G Index | 127 | Maximum value of g such that the given author has published at least g papers that have each been cited at least g^2 times. |
| i10 Index | 109 | Number of documents with at least 10 citations recieved. |
Excellence
Reflects an author's academic visibility and the exceptional quality and influence of their most highly cited works.
| Citation Score | 0.607 | Ratio between 0 and 1 being 0 corresponding to the citation percentile being 0 the 0th and 1 the 100th. |
|---|---|---|
| Citation Normalized Percentile | 0.63 | Citation percentile normalized to 1 (0 worst, 1 best) of the position in citations rankin within the field. Provided by OpenAlex. |
| Higly Cited Papers (top 10%) | 47 | Count of publications falling on or above the 90th citation percentile in the cohort of publications of the same type, year and discipline. |
| Relative Higly Cited Papers | 2.461 | Quotient between the real number of Highly Cited Papers (HCP) and expected number of HCP's that is the 10% of total documents. |
| Outstanding Papers (top 1%) | 6 | Count of publications falling on or above the 99th citation percentile in the cohort of publications of the same type, year and discipline. |
| Relative Outstanding Papers | 3.141 | Quotient between the real number of Outstanding Papers (OP) and expected number of OP's that is the 1% of total documents. |
| Outstanding Papers (top 0.1%) | 2 | Count of publications falling on or above the 99.9th citation percentile in the cohort of publications of the same type, year and discipline. |
| Hot Papers | 7 | Using only the citations recieved in the last 6 months: documents falling on or above the 99th citation percentile in the cohort of publications of the same type, year and discipline. |
Interaction within community
Leadership
Reflects an author's efforts and commitment in leading research initiatives.
| Docs Leadership | 81 | Number of documents lead by the author. |
|---|---|---|
| % Leadership | 42.41 | Percentage of documents lead by the author. |
| Docs International Leadership | 24 | Number of documents in international collaboration lead by the author. |
| % International Leadership | 12.57 | Percentage of documents in international collaboration lead by the author. |
| Principal Investigator | 0 | Number of times where the author served as the lead researcher in a project. |
| Associations Founded | 0 | Number of associations founded by the author. |
| Societies Founded | 0 | Number of scientific or professional societies established by the author. |
| Foundations Founded | 0 | Number of research-related foundations established by the author. |
| Councils | 0 | Number of councils founded by author. |
Cooperation
Reflects a researcher's ability to navigate and thrive in varied academic and research environments, highlighting adaptability, resourcefulness, and the capacity to build and maintain collaborative relationships across the spectrum of their career.
| Authors/Paper | 46.53 | Average number of authors per document. |
|---|---|---|
| % Highly Authored Papers | 2.62 | Percentage of documents with 25 or more authors. |
| Countries/Paper | 1.41 | Average number of different countries in the author's affiliation line per document. |
| Docs International Collaboration | 65 | Number of documents reporting two or more different countries in the author's affiliation line. |
| % International Collaboration | 34.03 | Percentage of documents reporting two or more diffetent countries in the author's affiliation line. |
Community Support
Reflects an author's contributions to the academic community beyond their own research.
| Peer Review Counts | 4 | Number of times the author peer-reviewed publications. |
|---|---|---|
| Society Membership | 2 | Number of societies of wich the author is a member. |
| Society Memberships | 0 | Memberships held by the author in scientific or professional societies. |
| Editorial Board Memberships | 0 | Number of journals where the author has been member of editorial board. |
| Panelists | 0 | Number of times the author have been a panelist in the European Research Council (ERC) calls. |
Community Recognition
Reflects the academic community's acknowledgment and appreciation of an author's contributions.
| Distinctions | 1 | Number of times the author have recieved a distinction for its career. |
|---|---|---|
| Invitations | 1 | Number of times the author has been invited to talks, professorships, expositions or demonstrations. |
| Talks | 0 | Number of times the author has been invited to talks. |
| Professorships | 0 | Number of times the author has been invited to professorhips. |
| Commissioned Reports | 0 | Commissioned reports done by the author. |
Interaction with society
Openness
Reflects an author's commitment to making their research freely accessible and open to the public.
| Open Access Documents | 132 | Number of documents in Open Access mode. |
|---|---|---|
| % Open Access Documents | 69.11 | Percentage of documents in Open Access mode. |
| Open Access Gold | 42 | Number of documents published in an OA journal that is indexed by the DOAJ. |
| Open Access Green | 20 | Toll-access on the publisher landing page, but there is a free copy in an OA repository. |
| Open Access Hybrid | 24 | Free under an open license in a toll-access journal. |
| Open Access Bronze | 46 | Free to read on the publisher landing page, but without any identifiable license. |
| Open Access Closed | 59 | Non Open Access documents. |
Transference
Reflects an author's commitment to making their research a practical application and real-world impact of an author's research.
| Patents | 0 | Intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an enabling disclosure of the invention. |
|---|---|---|
| Advisory Boards | 0 | Number of advisory boards of which the author is member. |
| Companies | 0 | Number of companies created or founded by the author. |
Fundraising
Reflects an author's ability in securing project funding from major global entities, showcasing your ability to drive research initiatives forward.
| Funding Counts | 0 | Number of activities reported as funding recieved. |
|---|---|---|
| ERC Grantees | 0 | Researchers awarded grants from the European Research Council. |